PDB 6huc

PDB Links
Overview

PDB Information

PDB	6HUC
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-05
Resolution	3.000
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6huc

PDB 6huc

6huca

PDB Chain 6huca

6hucA

PDB Chain 6hucA

6hucb

PDB Chain 6hucb

6hucB

PDB Chain 6hucB

6hucC

PDB Chain 6hucC

6hucD

PDB Chain 6hucD

6hucE

PDB Chain 6hucE

6hucF

PDB Chain 6hucF

6hucG

PDB Chain 6hucG

6hucH

PDB Chain 6hucH

6hucI

PDB Chain 6hucI

6hucJ

PDB Chain 6hucJ

6hucK

PDB Chain 6hucK

6hucL

PDB Chain 6hucL

6hucM

PDB Chain 6hucM

6hucN

PDB Chain 6hucN

6hucO

PDB Chain 6hucO

6hucP

PDB Chain 6hucP

6hucQ

PDB Chain 6hucQ

6hucR

PDB Chain 6hucR

6hucS

PDB Chain 6hucS

6hucT

PDB Chain 6hucT

6hucU

PDB Chain 6hucU

6hucV

PDB Chain 6hucV

6hucW

PDB Chain 6hucW

6hucX

PDB Chain 6hucX

6hucY

PDB Chain 6hucY

6hucZ

PDB Chain 6hucZ

6huca00

CATH Domain 6huca00

6hucA00

CATH Domain 6hucA00

6hucb00

CATH Domain 6hucb00

6hucB00

CATH Domain 6hucB00

6hucC00

CATH Domain 6hucC00

6hucD00

CATH Domain 6hucD00

6hucE00

CATH Domain 6hucE00

6hucF00

CATH Domain 6hucF00

6hucG00

CATH Domain 6hucG00

6hucH00

CATH Domain 6hucH00

6hucI00

CATH Domain 6hucI00

6hucJ00

CATH Domain 6hucJ00

6hucK00

CATH Domain 6hucK00

6hucL00

CATH Domain 6hucL00

6hucM00

CATH Domain 6hucM00

6hucN00

CATH Domain 6hucN00

6hucO00

CATH Domain 6hucO00

6hucP00

CATH Domain 6hucP00

6hucQ00

CATH Domain 6hucQ00

6hucR00

CATH Domain 6hucR00

6hucS00

CATH Domain 6hucS00

6hucT00

CATH Domain 6hucT00

6hucU00

CATH Domain 6hucU00

6hucV00

CATH Domain 6hucV00

6hucW00

CATH Domain 6hucW00

6hucX00

CATH Domain 6hucX00

6hucY00

CATH Domain 6hucY00

6hucZ00

CATH Domain 6hucZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6huca00	04 Feb, 2019	3.60.20.10	Assigned
6hucA00	04 Feb, 2019	3.60.20.10	Assigned
6hucb00	04 Feb, 2019	3.60.20.10	Assigned
6hucB00	04 Feb, 2019	3.60.20.10	Assigned
6hucC00	04 Feb, 2019	3.60.20.10	Assigned
6hucD00	04 Feb, 2019	3.60.20.10	Assigned
6hucE00	04 Feb, 2019	3.60.20.10	Assigned
6hucF00	04 Feb, 2019	3.60.20.10	Assigned
6hucG00	04 Feb, 2019	3.60.20.10	Assigned
6hucH00	04 Feb, 2019	3.60.20.10	Assigned
6hucI00	04 Feb, 2019	3.60.20.10	Assigned
6hucJ00	04 Feb, 2019	3.60.20.10	Assigned
6hucK00	04 Feb, 2019	3.60.20.10	Assigned
6hucL00	04 Feb, 2019	3.60.20.10	Assigned
6hucM00	04 Feb, 2019	3.60.20.10	Assigned
6hucN00	04 Feb, 2019	3.60.20.10	Assigned
6hucO00	04 Feb, 2019	3.60.20.10	Assigned
6hucP00	04 Feb, 2019	3.60.20.10	Assigned
6hucQ00	04 Feb, 2019	3.60.20.10	Assigned
6hucR00	04 Feb, 2019	3.60.20.10	Assigned
6hucS00	04 Feb, 2019	3.60.20.10	Assigned
6hucT00	04 Feb, 2019	3.60.20.10	Assigned
6hucU00	04 Feb, 2019	3.60.20.10	Assigned
6hucV00	04 Feb, 2019	3.60.20.10	Assigned
6hucW00	04 Feb, 2019	3.60.20.10	Assigned
6hucX00	04 Feb, 2019	3.60.20.10	Assigned
6hucY00	04 Feb, 2019	3.60.20.10	Assigned
6hucZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7