PDB 6htr

PDB Links
Overview

PDB Information

PDB	6HTR
Method	X-RAY DIFFRACTION
Host Organism	Saccharomyces cerevisiae S288c
Gene Source	Homo sapiens
Primary Citation	Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits. Xin, B.T., Huber, E.M., de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Janssens, M., Weyburne, E.S., Kisselev, A.F., Florea, B.I., Driessen, C., van der Marel, G.A., Groll, M., Overkleeft, H.S. J.Med.Chem.
Header	Hydrolase
Released	2018-10-04
Resolution	2.600
CATH Insert Date	03 Feb, 2019

PDB Images (57)

6htr

PDB 6htr

6htra

PDB Chain 6htra

6htrA

PDB Chain 6htrA

6htrb

PDB Chain 6htrb

6htrB

PDB Chain 6htrB

6htrC

PDB Chain 6htrC

6htrD

PDB Chain 6htrD

6htrE

PDB Chain 6htrE

6htrF

PDB Chain 6htrF

6htrG

PDB Chain 6htrG

6htrH

PDB Chain 6htrH

6htrI

PDB Chain 6htrI

6htrJ

PDB Chain 6htrJ

6htrK

PDB Chain 6htrK

6htrL

PDB Chain 6htrL

6htrM

PDB Chain 6htrM

6htrN

PDB Chain 6htrN

6htrO

PDB Chain 6htrO

6htrP

PDB Chain 6htrP

6htrQ

PDB Chain 6htrQ

6htrR

PDB Chain 6htrR

6htrS

PDB Chain 6htrS

6htrT

PDB Chain 6htrT

6htrU

PDB Chain 6htrU

6htrV

PDB Chain 6htrV

6htrW

PDB Chain 6htrW

6htrX

PDB Chain 6htrX

6htrY

PDB Chain 6htrY

6htrZ

PDB Chain 6htrZ

6htra00

CATH Domain 6htra00

6htrA00

CATH Domain 6htrA00

6htrb00

CATH Domain 6htrb00

6htrB00

CATH Domain 6htrB00

6htrC00

CATH Domain 6htrC00

6htrD00

CATH Domain 6htrD00

6htrE00

CATH Domain 6htrE00

6htrF00

CATH Domain 6htrF00

6htrG00

CATH Domain 6htrG00

6htrH00

CATH Domain 6htrH00

6htrI00

CATH Domain 6htrI00

6htrJ00

CATH Domain 6htrJ00

6htrK00

CATH Domain 6htrK00

6htrL00

CATH Domain 6htrL00

6htrM00

CATH Domain 6htrM00

6htrN00

CATH Domain 6htrN00

6htrO00

CATH Domain 6htrO00

6htrP00

CATH Domain 6htrP00

6htrQ00

CATH Domain 6htrQ00

6htrR00

CATH Domain 6htrR00

6htrS00

CATH Domain 6htrS00

6htrT00

CATH Domain 6htrT00

6htrU00

CATH Domain 6htrU00

6htrV00

CATH Domain 6htrV00

6htrW00

CATH Domain 6htrW00

6htrX00

CATH Domain 6htrX00

6htrY00

CATH Domain 6htrY00

6htrZ00

CATH Domain 6htrZ00

PDB Prints

PDB Chains (28)

Chain ID	Date inserted into CATH	CATH Status
a	03 Feb, 2019	Chopped
A	03 Feb, 2019	Chopped
b	03 Feb, 2019	Chopped
B	03 Feb, 2019	Chopped
C	03 Feb, 2019	Chopped
D	03 Feb, 2019	Chopped
E	03 Feb, 2019	Chopped
F	03 Feb, 2019	Chopped
G	03 Feb, 2019	Chopped
H	03 Feb, 2019	Chopped
I	03 Feb, 2019	Chopped
J	03 Feb, 2019	Chopped
K	03 Feb, 2019	Chopped
L	03 Feb, 2019	Chopped
M	03 Feb, 2019	Chopped
N	03 Feb, 2019	Chopped
O	03 Feb, 2019	Chopped
P	03 Feb, 2019	Chopped
Q	03 Feb, 2019	Chopped
R	03 Feb, 2019	Chopped
S	03 Feb, 2019	Chopped
T	03 Feb, 2019	Chopped
U	03 Feb, 2019	Chopped
V	03 Feb, 2019	Chopped
W	03 Feb, 2019	Chopped
X	03 Feb, 2019	Chopped
Y	03 Feb, 2019	Chopped
Z	03 Feb, 2019	Chopped

CATH Domains (28)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6htra00	04 Feb, 2019	3.60.20.10	Assigned
6htrA00	04 Feb, 2019	3.60.20.10	Assigned
6htrb00	04 Feb, 2019	3.60.20.10	Assigned
6htrB00	04 Feb, 2019	3.60.20.10	Assigned
6htrC00	04 Feb, 2019	3.60.20.10	Assigned
6htrD00	04 Feb, 2019	3.60.20.10	Assigned
6htrE00	04 Feb, 2019	3.60.20.10	Assigned
6htrF00	04 Feb, 2019	3.60.20.10	Assigned
6htrG00	04 Feb, 2019	3.60.20.10	Assigned
6htrH00	04 Feb, 2019	3.60.20.10	Assigned
6htrI00	04 Feb, 2019	3.60.20.10	Assigned
6htrJ00	04 Feb, 2019	3.60.20.10	Assigned
6htrK00	04 Feb, 2019	3.60.20.10	Assigned
6htrL00	04 Feb, 2019	3.60.20.10	Assigned
6htrM00	04 Feb, 2019	3.60.20.10	Assigned
6htrN00	04 Feb, 2019	3.60.20.10	Assigned
6htrO00	04 Feb, 2019	3.60.20.10	Assigned
6htrP00	04 Feb, 2019	3.60.20.10	Assigned
6htrQ00	04 Feb, 2019	3.60.20.10	Assigned
6htrR00	04 Feb, 2019	3.60.20.10	Assigned
6htrS00	04 Feb, 2019	3.60.20.10	Assigned
6htrT00	04 Feb, 2019	3.60.20.10	Assigned
6htrU00	04 Feb, 2019	3.60.20.10	Assigned
6htrV00	04 Feb, 2019	3.60.20.10	Assigned
6htrW00	04 Feb, 2019	3.60.20.10	Assigned
6htrX00	04 Feb, 2019	3.60.20.10	Assigned
6htrY00	04 Feb, 2019	3.60.20.10	Assigned
6htrZ00	04 Feb, 2019	3.60.20.10	Assigned

UniProtKB Entries (28)

Accession	Gene ID	Taxon	Description
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P23638	PSA3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-3
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23639	PSA2_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-2
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5
P40303	PSA4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-4
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
P30657	PSB7_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-7
P21242	PSA7_YEAST	Saccharomyces cerevisiae S288C	Probable proteasome subunit alpha type-7
P38624	PSB1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-1
P32379	PSA5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-5
P21243	PSA1_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-1
Q99436	PSB7_HUMAN	Homo sapiens	Proteasome subunit beta type-7
P25451	PSB3_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-3
P40302	PSA6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit alpha type-6
P23724	PSB6_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-6
P22141	PSB4_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-4
P30656	PSB5_YEAST	Saccharomyces cerevisiae S288C	Proteasome subunit beta type-5