PDB Information

PDB6GQK
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Boyd, S., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hardy, C.J., Hunt, T., Jones, R.D.O., Li, X., Moleva, O., Ogg, D., Overman, R.C., Packer, M.J., Pearson, S., Schimpl, M., Shao, W., Smith, A., Smith, J.M., Stead, D., Stokes, S., Tucker, M., Ye, Y.
J. Med. Chem.
HeaderSignaling Protein
Released2018-06-07
Resolution2.310
CATH Insert Date23 Sep, 2018

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 23 Sep, 2018 Chopped
B 23 Sep, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6gqkA01 24 Sep, 2018 3.30.200.20 Assigned
6gqkA02 24 Sep, 2018 1.10.510.10 Assigned
6gqkB01 24 Sep, 2018 3.30.200.20 Assigned
6gqkB02 24 Sep, 2018 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P10721 KIT_HUMAN Homo sapiens Mast/stem cell growth factor receptor Kit
P10721 KIT_HUMAN Homo sapiens Mast/stem cell growth factor receptor Kit
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