PDB 6eie

PDB Information

PDB6EIE
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig, R.C., Sautier, B., Schroeder, J., Moosmayer, D., Hilpmann, A., Stegmann, C.M., Werbeck, N.D., Briem, H., Boemer, U., Weiske, J., Badock, V., Mastouri, J., Petersen, K., Siemeister, G., Kahmann, J.D., Wegener, D., Bohnke, N., Eis, K., Graham, K., Wortmann, L., von Nussbaum, F., Bader, B.
Proc. Natl. Acad. Sci. U.S.A.
HeaderSignaling Protein
Released2017-09-19
Resolution2.720
CATH Insert Date10 Feb, 2019

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 10 Feb, 2019 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6eieA01 11 Feb, 2019 1.20.870.10 Assigned
6eieA02 11 Feb, 2019 1.10.840.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q07890 SOS2_HUMAN Homo sapiens Son of sevenless homolog 2