PDB Information

PDB6DBN
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Fensome, A., Ambler, C.M., Arnold, E., Banker, M.E., Brown, M.F., Chrencik, J., Clark, J.D., Dowty, M.E., Efremov, I.V., Flick, A., Gerstenberger, B.S., Gopalsamy, A., Hayward, M.M., Hegen, M., Hollingshead, B.D., Jussif, J., Knafels, J.D., Limburg, D.C., Lin, D., Lin, T.H., Pierce, B.S., Saiah, E., Sharma, R., Symanowicz, P.T., Telliez, J.B., Trujillo, J.I., Vajdos, F.F., Vincent, F., Wan, Z.K., Xing, L., Yang, X., Yang, X., Zhang, L.
J. Med. Chem.
HeaderTransferase
Released2018-05-03
Resolution2.480
CATH Insert Date02 Sep, 2018

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6dbnA01 03 Sep, 2018 3.30.200.20 Assigned
6dbnA02 03 Sep, 2018 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P23458 JAK1_HUMAN Homo sapiens Tyrosine-protein kinase JAK1