PDB Information

PDB6DBM
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
Fensome, A., Ambler, C.M., Arnold, E., Banker, M.E., Brown, M.F., Chrencik, J., Clark, J.D., Dowty, M.E., Efremov, I.V., Flick, A., Gerstenberger, B.S., Gopalsamy, A., Hayward, M.M., Hegen, M., Hollingshead, B.D., Jussif, J., Knafels, J.D., Limburg, D.C., Lin, D., Lin, T.H., Pierce, B.S., Saiah, E., Sharma, R., Symanowicz, P.T., Telliez, J.B., Trujillo, J.I., Vajdos, F.F., Vincent, F., Wan, Z.K., Xing, L., Yang, X., Yang, X., Zhang, L.
J. Med. Chem.
HeaderTransferase
Released2018-05-03
Resolution2.370
CATH Insert Date02 Sep, 2018

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6dbmA01 03 Sep, 2018 3.30.200.20 Assigned
6dbmA02 03 Sep, 2018 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P29597 TYK2_HUMAN Homo sapiens Non-receptor tyrosine-protein kinase TYK2