PDB 6d5m

PDB Information

PDB6D5M
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W.
J. Med. Chem.
HeaderSignaling Protein
Released2018-04-19
Resolution2.080
CATH Insert Date23 Sep, 2018

PDB Images (8)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
Q 23 Sep, 2018 Chopped
R 23 Sep, 2018 Chopped
S 23 Sep, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6d5mQ00 24 Sep, 2018 3.40.50.300 Assigned
6d5mR00 24 Sep, 2018 3.40.50.300 Assigned
6d5mS01 24 Sep, 2018 1.20.870.10 Assigned
6d5mS02 24 Sep, 2018 1.10.840.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q07889 SOS1_HUMAN Homo sapiens Son of sevenless homolog 1
P01112 RASH_HUMAN Homo sapiens GTPase HRas
P01112 RASH_HUMAN Homo sapiens GTPase HRas