PDB 6ckx

PDB Information

PDB6CKX
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
Ito, M., Tanaka, T., Toita, A., Uchiyama, N., Kokubo, H., Morishita, N., Klein, M.G., Zou, H., Murakami, M., Kondo, M., Sameshima, T., Araki, S., Endo, S., Kawamoto, T., Morin, G.B., Aparicio, S.A., Nakanishi, A., Maezaki, H., Imaeda, Y.
J. Med. Chem.
HeaderTransferase/Inhibitor
Released2018-03-01
Resolution2.800
CATH Insert Date02 Sep, 2018

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 02 Sep, 2018 Chopped
B 02 Sep, 2018 Chopped
C 02 Sep, 2018 Chopped
D 02 Sep, 2018 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
6ckxA01 03 Sep, 2018 3.30.200.20 Assigned
6ckxA02 03 Sep, 2018 1.10.510.10 Assigned
6ckxB01 03 Sep, 2018 1.10.472.10 Assigned
6ckxB02 03 Sep, 2018 1.10.472.10 Assigned
6ckxC01 03 Sep, 2018 3.30.200.20 Assigned
6ckxC02 03 Sep, 2018 1.10.510.10 Assigned
6ckxD01 03 Sep, 2018 1.10.472.10 Assigned
6ckxD02 03 Sep, 2018 1.10.472.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O75909 CCNK_HUMAN Homo sapiens Cyclin-K
Q9NYV4 CDK12_HUMAN Homo sapiens Cyclin-dependent kinase 12
O75909 CCNK_HUMAN Homo sapiens Cyclin-K
Q9NYV4 CDK12_HUMAN Homo sapiens Cyclin-dependent kinase 12