PDB Information

PDB6BL1
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
Jakob, C.G., Upadhyay, A.K., Donner, P.L., Nicholl, E., Addo, S.N., Qiu, W., Ling, C., Gopalakrishnan, S.M., Torrent, M., Cepa, S.P., Shanley, J., Shoemaker, A.R., Sun, C.C., Vasudevan, A., Woller, K.R., Shotwell, J.B., Shaw, B., Bian, Z., Hutti, J.E.
J. Med. Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2017-11-09
Resolution2.020
CATH Insert Date29 Jul, 2018

PDB Images (7)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 29 Jul, 2018 Chopped
B 29 Jul, 2018 Chopped
C 29 Jul, 2018 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
6bl1A00 30 Jul, 2018 3.40.718.10 Assigned
6bl1B00 30 Jul, 2018 3.40.718.10 Assigned
6bl1C00 30 Jul, 2018 3.40.718.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic