PDB 5yls

PDB Information

PDB5YLS
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceSus scrofa
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Yang, J.H., Yan, W., Yu, Y.M., Wang, Y.X., Yang, T., Xue, L.L., Yuan, X., Long, C.F., Liu, Z.W., Chen, X.X., Hu, M.S., Zheng, L., Qiu, Q., Pei, H.Y., Li, D., Wang, F., Bai, P., Wen, J.L., Ye, H.Y., Chen, L.J.
J. Biol. Chem.
HeaderStructural Protein
Released2017-10-18
Resolution3.000
CATH Insert Date03 Jun, 2018

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped
E 03 Jun, 2018 Chopped
F 03 Jun, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5ylsA01 28 Jun, 2018 3.40.50.1440 Assigned
5ylsA02 28 Jun, 2018 3.30.1330.20 Assigned
5ylsA03 28 Jun, 2018 1.10.287.600 Assigned
5ylsB01 28 Jun, 2018 3.40.50.1440 Assigned
5ylsB02 28 Jun, 2018 3.30.1330.20 Assigned
5ylsB03 28 Jun, 2018 1.10.287.600 Assigned
5ylsC01 28 Jun, 2018 3.40.50.1440 Assigned
5ylsC02 28 Jun, 2018 3.30.1330.20 Assigned
5ylsC03 28 Jun, 2018 1.10.287.600 Assigned
5ylsD01 28 Jun, 2018 3.40.50.1440 Assigned
5ylsD02 28 Jun, 2018 3.30.1330.20 Assigned
5ylsD03 28 Jun, 2018 1.10.287.600 Assigned
5ylsE01 28 Jun, 2018 6.10.280.30 Assigned
5ylsF01 28 Jun, 2018 3.40.50.11480 Assigned
5ylsF02 28 Jun, 2018 3.30.470.20 Assigned
5ylsF03 28 Jun, 2018 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P02554 TBB_PIG Sus scrofa Tubulin beta chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain