PDB 5yl2

PDB Information

PDB5YL2
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceSus scrofa
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Jianhong, Y., Wei, Y., Yamei, Y., Yuxi, W., Tao, Y., Linlin, X., Xue, Y., Caofeng, L., Zuowei, L., Xiaoxin, C., Mengshi, H., Li, Z., Qiang, Q., Heying, P., Dan, L., Fang, W., Peng, B., Jiaolin, W., Haoyu, Y., Lijuan, C.
J. Biol. Chem.
HeaderStructural Protein
Released2017-10-16
Resolution2.090
CATH Insert Date03 Jun, 2018

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped
E 03 Jun, 2018 Chopped
F 03 Jun, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5yl2A01 28 Jun, 2018 3.40.50.1440 Assigned
5yl2A02 28 Jun, 2018 3.30.1330.20 Assigned
5yl2A03 28 Jun, 2018 1.10.287.600 Assigned
5yl2B01 28 Jun, 2018 3.40.50.1440 Assigned
5yl2B02 28 Jun, 2018 3.30.1330.20 Assigned
5yl2B03 28 Jun, 2018 1.10.287.600 Assigned
5yl2C01 28 Jun, 2018 3.40.50.1440 Assigned
5yl2C02 28 Jun, 2018 3.30.1330.20 Assigned
5yl2C03 28 Jun, 2018 1.10.287.600 Assigned
5yl2D01 28 Jun, 2018 3.40.50.1440 Assigned
5yl2D02 28 Jun, 2018 3.30.1330.20 Assigned
5yl2D03 28 Jun, 2018 1.10.287.600 Assigned
5yl2E01 28 Jun, 2018 6.10.280.30 Assigned
5yl2F01 28 Jun, 2018 3.40.50.11480 Assigned
5yl2F02 28 Jun, 2018 3.30.470.20 Assigned
5yl2F03 28 Jun, 2018 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
P02554 TBB_PIG Sus scrofa Tubulin beta chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain
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