PDB 5xkm

PDB Information

PDB5XKM
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.
Mikami, S., Sasaki, S., Asano, Y., Ujikawa, O., Fukumoto, S., Nakashima, K., Oki, H., Kamiguchi, N., Imada, H., Iwashita, H., Taniguchi, T.
J. Med. Chem.
HeaderHydrolase
Released2017-05-08
Resolution2.160
CATH Insert Date14 Nov, 2017

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5xkmA00 10 Dec, 2017 1.10.1300.10 Assigned
5xkmB00 10 Dec, 2017 1.10.1300.10 Assigned
5xkmC00 10 Dec, 2017 1.10.1300.10 Assigned
5xkmD00 10 Dec, 2017 1.10.1300.10 Assigned
5xkmE00 10 Dec, 2017 1.10.1300.10 Assigned
5xkmF00 10 Dec, 2017 1.10.1300.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase