The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
Siu, T., Brubaker, J., Fuller, P., Torres, L., Zeng, H., Close, J., Mampreian, D.M., Shi, F., Liu, D., Fradera, X., Johnson, K., Bays, N., Kadic, E., He, F., Goldenblatt, P., Shaffer, L., Patel, S.B., Lesburg, C.A., Alpert, C., Dorosh, L., Deshmukh, S.V., Yu, H., Klappenbach, J., Elwood, F., Dinsmore, C.J., Fernandez, R., Moy, L., Young, J.R.
J. Med. Chem.