PDB 5wfr

PDB Information

PDB5WFR
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Burns, M.C., Howes, J.E., Sun, Q., Little, A.J., Camper, D.V., Abbott, J.R., Phan, J., Lee, T., Waterson, A.G., Rossanese, O.W., Fesik, S.W.
Anal. Biochem.
HeaderSignaling Protein
Released2017-07-12
Resolution2.460
CATH Insert Date03 Jun, 2018

PDB Images (8)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
N 03 Jun, 2018 Chopped
Q 03 Jun, 2018 Chopped
R 03 Jun, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5wfrN01 28 Jun, 2018 1.20.870.10 Assigned
5wfrN02 28 Jun, 2018 1.10.840.10 Assigned
5wfrQ00 28 Jun, 2018 3.40.50.300 Assigned
5wfrR00 28 Jun, 2018 3.40.50.300 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
Q07889 SOS1_HUMAN Homo sapiens Son of sevenless homolog 1
P01112 RASH_HUMAN Homo sapiens GTPase HRas
P01112 RASH_HUMAN Homo sapiens GTPase HRas