PDB 5w8j

PDB Information

PDB5W8J
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Rai, G., Brimacombe, K.R., Mott, B.T., Urban, D.J., Hu, X., Yang, S.M., Lee, T.D., Cheff, D.M., Kouznetsova, J., Benavides, G.A., Pohida, K., Kuenstner, E.J., Luci, D.K., Lukacs, C.M., Davies, D.R., Dranow, D.M., Zhu, H., Sulikowski, G., Moore, W.J., Stott, G.M., Flint, A.J., Hall, M.D., Darley-Usmar, V.M., Neckers, L.M., Dang, C.V., Waterson, A.G., Simeonov, A., Jadhav, A., Maloney, D.J.
J. Med. Chem.
HeaderOxidoreductase
Released2017-06-21
Resolution1.550
CATH Insert Date03 Jun, 2018

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5w8jA01 28 Jun, 2018 3.40.50.720 Assigned
5w8jA02 28 Jun, 2018 3.90.110.10 Assigned
5w8jB01 28 Jun, 2018 3.40.50.720 Assigned
5w8jB02 28 Jun, 2018 3.90.110.10 Assigned
5w8jC01 28 Jun, 2018 3.40.50.720 Assigned
5w8jC02 28 Jun, 2018 3.90.110.10 Assigned
5w8jD01 28 Jun, 2018 3.40.50.720 Assigned
5w8jD02 28 Jun, 2018 3.90.110.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain
P00338 LDHA_HUMAN Homo sapiens L-lactate dehydrogenase A chain