PDB 5w86

PDB Information

PDB5W86
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
Bhide, R.S., Keon, A., Weigelt, C., Sack, J.S., Schmidt, R.J., Lin, S., Xiao, H.Y., Spergel, S.H., Kempson, J., Pitts, W.J., Carman, J., Poss, M.A.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2017-06-21
Resolution2.610
CATH Insert Date14 Nov, 2017

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5w86A01 10 Dec, 2017 3.30.200.20 Assigned
5w86A02 10 Dec, 2017 1.10.510.10 Assigned
5w86B01 10 Dec, 2017 3.30.200.20 Assigned
5w86B02 10 Dec, 2017 1.10.510.10 Assigned
5w86C01 10 Dec, 2017 3.30.200.20 Assigned
5w86C02 10 Dec, 2017 1.10.510.10 Assigned
5w86D01 10 Dec, 2017 3.30.200.20 Assigned
5w86D02 10 Dec, 2017 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P52333 JAK3_HUMAN Homo sapiens Tyrosine-protein kinase JAK3
P52333 JAK3_HUMAN Homo sapiens Tyrosine-protein kinase JAK3
P52333 JAK3_HUMAN Homo sapiens Tyrosine-protein kinase JAK3
P52333 JAK3_HUMAN Homo sapiens Tyrosine-protein kinase JAK3