PDB Information

PDB5V8O
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Hall, J., Brault, A., Vincent, F., Weng, S., Wang, H., Dumlao, D., Aulabaugh, A., Aivazian, D., Castro, D., Chen, M., Culp, J., Dower, K., Gardner, J., Hawrylik, S., Golenbock, D., Hepworth, D., Horn, M., Jones, L., Jones, P., Latz, E., Li, J., Lin, L.L., Lin, W., Lin, D., Lovering, F., Niljanskul, N., Nistler, R., Pierce, B., Plotnikova, O., Schmitt, D., Shanker, S., Smith, J., Snyder, W., Subashi, T., Trujillo, J., Tyminski, E., Wang, G., Wong, J., Lefker, B., Dakin, L., Leach, K.
PLoS ONE
HeaderTransferase/Transferase Inhibitor
Released2017-03-22
Resolution3.100
CATH Insert Date14 Nov, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5v8oA01 10 Dec, 2017 1.10.1410.40 Assigned
5v8oA02 10 Dec, 2017 3.30.460.90 Assigned
5v8oB01 10 Dec, 2017 1.10.1410.40 Assigned
5v8oB02 10 Dec, 2017 3.30.460.90 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q8N884 CGAS_HUMAN Homo sapiens Cyclic GMP-AMP synthase
Q8N884 CGAS_HUMAN Homo sapiens Cyclic GMP-AMP synthase