Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Kirschberg, T.A., Metobo, S., Clarke, M.O., Aktoudianakis, V., Babusis, D., Barauskas, O., Birkus, G., Butler, T., Byun, D., Chin, G., Doerffler, E., Edwards, T.E., Fenaux, M., Lee, R., Lew, W., Mish, M.R., Murakami, E., Park, Y., Squires, N.H., Tirunagari, N., Wang, T., Whitcomb, M., Xu, J., Yang, H., Ye, H., Zhang, L., Appleby, T.C., Feng, J.Y., Ray, A.S., Cho, A., Kim, C.U.
Bioorg. Med. Chem. Lett.
