PDB Information

PDB5UIU
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
Lee, K.L., Ambler, C.M., Anderson, D.R., Boscoe, B.P., Bree, A.G., Brodfuehrer, J.I., Chang, J.S., Choi, C., Chung, S., Curran, K.J., Day, J.E., Dehnhardt, C.M., Dower, K., Drozda, S.E., Frisbie, R.K., Gavrin, L.K., Goldberg, J.A., Han, S., Hegen, M., Hepworth, D., Hope, H.R., Kamtekar, S., Kilty, I.C., Lee, A., Lin, L.L., Lovering, F.E., Lowe, M.D., Mathias, J.P., Morgan, H.M., Murphy, E.A., Papaioannou, N., Patny, A., Pierce, B.S., Rao, V.R., Saiah, E., Samardjiev, I.J., Samas, B.M., Shen, M.W.H., Shin, J.H., Soutter, H.H., Strohbach, J.W., Symanowicz, P.T., Thomason, J.R., Trzupek, J.D., Vargas, R., Vincent, F., Yan, J., Zapf, C.W., Wright, S.W.
J. Med. Chem.
HeaderTransferase
Released2017-01-14
Resolution2.020
CATH Insert Date14 Nov, 2017

PDB Images (3)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Holding pen
B 14 Nov, 2017 Holding pen

CATH Domains (0)

Domain ID Date inserted into CATH Superfamily CATH Status

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4