PDB Information

PDB5UGA
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera aff. frugiperda 2 RZ-2014
Gene SourceHomo sapiens
Primary Citation
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.
Planken, S., Behenna, D.C., Nair, S.K., Johnson, T.O., Nagata, A., Almaden, C., Bailey, S., Ballard, T.E., Bernier, L., Cheng, H., Cho-Schultz, S., Dalvie, D., Deal, J.G., Dinh, D.M., Edwards, M.P., Ferre, R.A., Gajiwala, K.S., Hemkens, M., Kania, R.S., Kath, J.C., Matthews, J., Murray, B.W., Niessen, S., Orr, S.T., Pairish, M., Sach, N.W., Shen, H., Shi, M., Solowiej, J., Tran, K., Tseng, E., Vicini, P., Wang, Y., Weinrich, S.L., Zhou, R., Zientek, M., Liu, L., Luo, Y., Xin, S., Zhang, C., Lafontaine, J.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2017-01-07
Resolution1.820
CATH Insert Date07 May, 2017

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5ugaA01 25 May, 2017 3.30.200.20 Assigned
5ugaA02 25 May, 2017 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P00533 EGFR_HUMAN Homo sapiens Epidermal growth factor receptor