PDB 5u7l

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Overview

PDB Information

PDB	5U7L
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. Helal, C.J., Arnold, E.P., Boyden, T.L., Chang, C., Chappie, T.A., Fennell, K.F., Forman, M.D., Hajos, M., Harms, J.F., Hoffman, W.E., Humphrey, J.M., Kang, Z., Kleiman, R.J., Kormos, B.L., Lee, C.W., Lu, J., Maklad, N., McDowell, L., Mente, S., O'Connor, R.E., Pandit, J., Piotrowski, M., Schmidt, A.W., Schmidt, C.J., Ueno, H., Verhoest, P.R., Yang, E.X. J. Med. Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2016-12-12
Resolution	2.380
CATH Insert Date	14 Nov, 2017

PDB Images (7)

Image of CATH 5u7l

5u7l

PDB 5u7l

Image of CATH 5u7lA

5u7lA

PDB Chain 5u7lA

Image of CATH 5u7lB

5u7lB

PDB Chain 5u7lB

Image of CATH 5u7lC

5u7lC

PDB Chain 5u7lC

Image of CATH 5u7lA00

5u7lA00

CATH Domain 5u7lA00

Image of CATH 5u7lB00

5u7lB00

CATH Domain 5u7lB00

Image of CATH 5u7lC00

5u7lC00

CATH Domain 5u7lC00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped

CATH Domains (3)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5u7lA00	10 Dec, 2017	1.10.1300.10	Assigned
5u7lB00	10 Dec, 2017	1.10.1300.10	Assigned
5u7lC00	10 Dec, 2017	1.10.1300.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase