PDB Information

PDB5U7L
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
Helal, C.J., Arnold, E.P., Boyden, T.L., Chang, C., Chappie, T.A., Fennell, K.F., Forman, M.D., Hajos, M., Harms, J.F., Hoffman, W.E., Humphrey, J.M., Kang, Z., Kleiman, R.J., Kormos, B.L., Lee, C.W., Lu, J., Maklad, N., McDowell, L., Mente, S., O'Connor, R.E., Pandit, J., Piotrowski, M., Schmidt, A.W., Schmidt, C.J., Ueno, H., Verhoest, P.R., Yang, E.X.
J. Med. Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2016-12-12
Resolution2.380
CATH Insert Date14 Nov, 2017

PDB Images (7)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
5u7lA00 10 Dec, 2017 1.10.1300.10 Assigned
5u7lB00 10 Dec, 2017 1.10.1300.10 Assigned
5u7lC00 10 Dec, 2017 1.10.1300.10 Assigned

UniProtKB Entries (3)

Accession Gene ID Taxon Description
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408 PDE2A_HUMAN Homo sapiens cGMP-dependent 3',5'-cyclic phosphodiesterase