PDB 5tr6

PDB Information

PDB5TR6
MethodX-RAY DIFFRACTION
Host OrganismBaculovirus expression vector pFastBac1-HM
Gene SourceHomo sapiens
Primary Citation
Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Lam, B., Arikawa, Y., Cramlett, J., Dong, Q., de Jong, R., Feher, V., Grimshaw, C.E., Farrell, P.J., Hoffman, I.D., Jennings, A., Jones, B., Matuszkiewicz, J., Miura, J., Miyake, H., Natala, S.R., Shi, L., Takahashi, M., Taylor, E., Wyrick, C., Yano, J., Zalevsky, J., Nie, Z.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2016-10-25
Resolution1.930
CATH Insert Date04 Dec, 2016

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Dec, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5tr6A01 10 Dec, 2016 3.30.200.20 Assigned
5tr6A02 10 Dec, 2016 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P43405 KSYK_HUMAN Homo sapiens Tyrosine-protein kinase SYK