PDB 5tkd

PDB Information

PDB5TKD
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
Moslin, R., Gardner, D., Santella, J., Zhang, Y., Duncia, J.V., Liu, C., Lin, J., Tokarski, J.S., Strnad, J., Pedicord, D., Chen, J., Blat, Y., Zupa-Fernandez, A., Cheng, L., Sun, H., Chaudhry, C., Huang, C., D'Arienzo, C., Sack, J.S., Muckelbauer, J.K., Chang, C., Tredup, J., Xie, D., Aranibar, N., Burke, J.R., Carter, P.H., Weinstein, D.S.
Medchemcomm
HeaderTransferase
Released2016-10-06
Resolution1.920
CATH Insert Date08 Jan, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 09 Jan, 2017 Chopped
B 09 Jan, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5tkdA01 20 Jan, 2017 3.30.200.20 Assigned
5tkdA02 20 Jan, 2017 1.10.510.10 Assigned
5tkdB01 20 Jan, 2017 3.30.200.20 Assigned
5tkdB02 20 Jan, 2017 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P29597 TYK2_HUMAN Homo sapiens Non-receptor tyrosine-protein kinase TYK2
P29597 TYK2_HUMAN Homo sapiens Non-receptor tyrosine-protein kinase TYK2