PDB 5tcj

PDB Information

PDB5TCJ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T.
Nat. Chem. Biol.
HeaderLyase
Released2016-09-15
Resolution2.400
CATH Insert Date14 Nov, 2017

PDB Images (21)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
5tcjA00 10 Dec, 2017 3.20.20.70 Assigned
5tcjB01 10 Dec, 2017 3.40.50.1100 Assigned
5tcjB02 10 Dec, 2017 3.40.50.1100 Assigned
5tcjC00 10 Dec, 2017 3.20.20.70 Assigned
5tcjD01 10 Dec, 2017 3.40.50.1100 Assigned
5tcjD02 10 Dec, 2017 3.40.50.1100 Assigned
5tcjE00 10 Dec, 2017 3.20.20.70 Assigned
5tcjF01 10 Dec, 2017 3.40.50.1100 Assigned
5tcjF02 10 Dec, 2017 3.40.50.1100 Assigned
5tcjG00 10 Dec, 2017 3.20.20.70 Assigned
5tcjH01 10 Dec, 2017 3.40.50.1100 Assigned
5tcjH02 10 Dec, 2017 3.40.50.1100 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain