PDB 5tci

PDB Information

PDB5TCI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T.
Nat. Chem. Biol.
HeaderLyase
Released2016-09-15
Resolution2.450
CATH Insert Date14 Nov, 2017

PDB Images (21)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
5tciA00 10 Dec, 2017 3.20.20.70 Assigned
5tciB01 10 Dec, 2017 3.40.50.1100 Assigned
5tciB02 10 Dec, 2017 3.40.50.1100 Assigned
5tciC00 10 Dec, 2017 3.20.20.70 Assigned
5tciD01 10 Dec, 2017 3.40.50.1100 Assigned
5tciD02 10 Dec, 2017 3.40.50.1100 Assigned
5tciE00 10 Dec, 2017 3.20.20.70 Assigned
5tciF01 10 Dec, 2017 3.40.50.1100 Assigned
5tciF02 10 Dec, 2017 3.40.50.1100 Assigned
5tciG00 10 Dec, 2017 3.20.20.70 Assigned
5tciH01 10 Dec, 2017 3.40.50.1100 Assigned
5tciH02 10 Dec, 2017 3.40.50.1100 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain