PDB 5tch

PDB Information

PDB5TCH
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T.
Nat. Chem. Biol.
HeaderLyase
Released2016-09-15
Resolution2.350
CATH Insert Date14 Nov, 2017

PDB Images (21)

PDB Prints

PDB Chains (8)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
5tchA00 10 Dec, 2017 3.20.20.70 Assigned
5tchB01 10 Dec, 2017 3.40.50.1100 Assigned
5tchB02 10 Dec, 2017 3.40.50.1100 Assigned
5tchC00 10 Dec, 2017 3.20.20.70 Assigned
5tchD01 10 Dec, 2017 3.40.50.1100 Assigned
5tchD02 10 Dec, 2017 3.40.50.1100 Assigned
5tchE00 10 Dec, 2017 3.20.20.70 Assigned
5tchF01 10 Dec, 2017 3.40.50.1100 Assigned
5tchF02 10 Dec, 2017 3.40.50.1100 Assigned
5tchG00 10 Dec, 2017 3.20.20.70 Assigned
5tchH01 10 Dec, 2017 3.40.50.1100 Assigned
5tchH02 10 Dec, 2017 3.40.50.1100 Assigned

UniProtKB Entries (8)

Accession Gene ID Taxon Description
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain