PDB 5qii

PDB Information

PDB5QII
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1).
Li, J., Kennedy, L.J., Walker, S.J., Wang, H., Li, J.J., Hong, Z., O'Connor, S.P., Ye, X.Y., Chen, S., Wu, S., Yoon, D.S., Nayeem, A., Camac, D.M., Ramamurthy, V., Morin, P.E., Sheriff, S., Wang, M., Harper, T.W., Golla, R., Seethala, R., Harrity, T., Ponticiello, R.P., Morgan, N.N., Taylor, J.R., Zebo, R., Maxwell, B., Moulin, F., Gordon, D.A., Robl, J.A.
ACS Med Chem Lett
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2018-07-03
Resolution2.450
CATH Insert Date23 Dec, 2018

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 23 Dec, 2018 Chopped
B 23 Dec, 2018 Chopped
D 23 Dec, 2018 Chopped
E 23 Dec, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5qiiA00 26 Dec, 2018 3.40.50.720 Assigned
5qiiB00 26 Dec, 2018 3.40.50.720 Assigned
5qiiD01 26 Dec, 2018 3.40.50.720 Assigned
5qiiE00 26 Dec, 2018 3.40.50.720 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845 DHI1_HUMAN Homo sapiens Corticosteroid 11-beta-dehydrogenase isozyme 1