PDB 5ovg

PDB Information

PDB5OVG
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Hillig, R.C., Sautier, B., Schroeder, J., Moosmayer, D., Hilpmann, A., Stegmann, C.M., Werbeck, N.D., Briem, H., Boemer, U., Weiske, J., Badock, V., Mastouri, J., Petersen, K., Siemeister, G., Kahmann, J.D., Wegener, D., Bohnke, N., Eis, K., Graham, K., Wortmann, L., von Nussbaum, F., Bader, B.
Proc. Natl. Acad. Sci. U.S.A.
HeaderSignaling Protein
Released2017-08-28
Resolution2.300
CATH Insert Date10 Feb, 2019

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 10 Feb, 2019 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5ovgA01 11 Feb, 2019 1.20.870.10 Assigned
5ovgA02 11 Feb, 2019 1.10.840.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q07889 SOS1_HUMAN Homo sapiens Son of sevenless homolog 1