PDB Information

PDB5OCW
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation
Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.
Abrahams, K.A., Cox, J.A.G., Futterer, K., Rullas, J., Ortega-Muro, F., Loman, N.J., Moynihan, P.J., Perez-Herran, E., Jimenez, E., Esquivias, J., Barros, D., Ballell, L., Alemparte, C., Besra, G.S.
Sci Rep
HeaderElectron Transport
Released2017-07-03
Resolution4.000
CATH Insert Date14 Nov, 2017

PDB Images (61)

PDB Prints

PDB Chains (24)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped
M 14 Nov, 2017 Chopped
N 14 Nov, 2017 Chopped
O 14 Nov, 2017 Chopped
P 14 Nov, 2017 Chopped
Q 14 Nov, 2017 Chopped
R 14 Nov, 2017 Chopped
S 14 Nov, 2017 Chopped
T 14 Nov, 2017 Chopped
U 14 Nov, 2017 Chopped
V 14 Nov, 2017 Chopped
W 14 Nov, 2017 Chopped
X 14 Nov, 2017 Chopped

CATH Domains (36)

Domain ID Date inserted into CATH Superfamily CATH Status
5ocwA00 10 Dec, 2017 3.20.20.70 Assigned
5ocwB01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwB02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwC00 10 Dec, 2017 3.20.20.70 Assigned
5ocwD01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwD02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwE00 10 Dec, 2017 3.20.20.70 Assigned
5ocwF01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwF02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwG00 10 Dec, 2017 3.20.20.70 Assigned
5ocwH01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwH02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwI00 10 Dec, 2017 3.20.20.70 Assigned
5ocwJ01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwJ02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwK00 10 Dec, 2017 3.20.20.70 Assigned
5ocwL01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwL02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwM00 10 Dec, 2017 3.20.20.70 Assigned
5ocwN01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwN02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwO00 10 Dec, 2017 3.20.20.70 Assigned
5ocwP01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwP02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwQ00 10 Dec, 2017 3.20.20.70 Assigned
5ocwR01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwR02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwS00 10 Dec, 2017 3.20.20.70 Assigned
5ocwT01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwT02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwU00 10 Dec, 2017 3.20.20.70 Assigned
5ocwV01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwV02 10 Dec, 2017 3.40.50.1100 Assigned
5ocwW00 10 Dec, 2017 3.20.20.70 Assigned
5ocwX01 10 Dec, 2017 3.40.50.1100 Assigned
5ocwX02 10 Dec, 2017 3.40.50.1100 Assigned

UniProtKB Entries (24)

Accession Gene ID Taxon Description
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFY1 TRPA_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase alpha chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain
P9WFX9 TRPB_MYCTU Mycobacterium tuberculosis H37Rv Tryptophan synthase beta chain