PDB Information

PDB5MVS
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
Mobitz, H., Machauer, R., Holzer, P., Vaupel, A., Stauffer, F., Ragot, C., Caravatti, G., Scheufler, C., Fernandez, C., Hommel, U., Tiedt, R., Beyer, K.S., Chen, C., Zhu, H., Gaul, C.
ACS Med Chem Lett
HeaderTransferase
Released2017-01-17
Resolution2.180
CATH Insert Date07 May, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5mvsA01 17 May, 2017 1.10.260.60 Assigned
5mvsA02 17 May, 2017 3.40.50.150 Assigned
5mvsB01 17 May, 2017 1.10.260.60 Assigned
5mvsB02 17 May, 2017 3.40.50.150 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q8TEK3 DOT1L_HUMAN Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific
Q8TEK3 DOT1L_HUMAN Homo sapiens Histone-lysine N-methyltransferase, H3 lysine-79 specific