PDB Information

PDB5M4P
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
Brough, P.A., Baker, L., Bedford, S., Brown, K., Chavda, S., Chell, V., D'Alessandro, J., Davies, N.G., Davis, B., Le Strat, L., Macias, A.T., Maddox, D., Mahon, P.C., Massey, A.J., Matassova, N., McKenna, S., Meissner, J.W., Moore, J.D., Murray, J.B., Northfield, C.J., Parry, C., Parsons, R., Roughley, S.D., Shaw, T., Simmonite, H., Stokes, S., Surgenor, A., Stefaniak, E., Robertson, A., Wang, Y., Webb, P., Whitehead, N., Wood, M.
J. Med. Chem.
HeaderTransferase
Released2016-10-18
Resolution2.300
CATH Insert Date07 May, 2017

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5m4pA01 15 May, 2017 1.20.140.20 Assigned
5m4pA02 15 May, 2017 3.30.565.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q15119 PDK2_HUMAN Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial