PDB 5k75

PDB Information

PDB5K75
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
Scott, J.S., Degorce, S.L., Anjum, R., Culshaw, J., Davies, R.D.M., Davies, N.L., Dillman, K.S., Dowling, J.E., Drew, L., Ferguson, A.D., Groombridge, S.D., Halsall, C.T., Hudson, J.A., Lamont, S., Lindsay, N.A., Marden, S.K., Mayo, M.F., Pease, J.E., Perkins, D.R., Pink, J.H., Robb, G.R., Rosen, A., Shen, M., McWhirter, C., Wu, D.
J. Med. Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-05-25
Resolution2.030
CATH Insert Date17 Dec, 2017

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 17 Dec, 2017 Chopped
B 17 Dec, 2017 Chopped
C 17 Dec, 2017 Chopped
D 17 Dec, 2017 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5k75A01 12 Jul, 2018 Check for files
5k75A02 12 Jul, 2018 Check for files
5k75B01 12 Jul, 2018 Check for files
5k75B02 12 Jul, 2018 Check for files
5k75C01 12 Jul, 2018 Check for files
5k75C02 12 Jul, 2018 Check for files
5k75D01 12 Jul, 2018 Check for files
5k75D02 12 Jul, 2018 Check for files

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4