PDB 5j87

PDB Information

PDB5J87
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor.
Liang, Q., Chen, Y., Yu, K., Chen, C., Zhang, S., Wang, A., Wang, W., Wu, H., Liu, X., Wang, B., Wang, L., Hu, Z., Wang, W., Ren, T., Zhang, S., Liu, Q., Yun, C.H., Liu, J.
Eur J Med Chem
HeaderTransferase/Transferase Inhibitor
Released2016-04-07
Resolution1.590
CATH Insert Date07 May, 2017

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Chopped
D 08 May, 2017 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5j87A01 12 May, 2017 3.30.200.20 Assigned
5j87A02 12 May, 2017 1.10.510.10 Assigned
5j87B01 12 May, 2017 3.30.200.20 Assigned
5j87B02 12 May, 2017 1.10.510.10 Assigned
5j87C01 12 May, 2017 3.30.200.20 Assigned
5j87C02 12 May, 2017 1.10.510.10 Assigned
5j87D01 12 May, 2017 3.30.200.20 Assigned
5j87D02 12 May, 2017 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK
Q06187 BTK_HUMAN Homo sapiens Tyrosine-protein kinase BTK