PDB 5hmk

PDB Information

PDB5HMK
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Bogen, S.L., Pan, W., Gibeau, C.R., Lahue, B.R., Ma, Y., Nair, L.G., Seigel, E., Shipps, G.W., Tian, Y., Wang, Y., Lin, Y., Liu, M., Liu, S., Mirza, A., Wang, X., Lipari, P., Seidel-Dugan, C., Hicklin, D.J., Bishop, W.R., Rindgen, D., Nomeir, A., Prosise, W., Reichert, P., Scapin, G., Strickland, C., Doll, R.J.
Acs Med.Chem.Lett.
HeaderLigase/Ligase Inhibitor
Released2016-01-16
Resolution2.170
CATH Insert Date17 Apr, 2016

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 18 Apr, 2016 Chopped
B 18 Apr, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5hmkA00 14 May, 2016 1.10.245.10 Assigned
5hmkB00 14 May, 2016 1.10.245.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2