PDB 5hex

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PDB Links
Overview

PDB Information

PDB	5HEX
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Lin, H., Zeng, J., Xie, R., Schulz, M.J., Tedesco, R., Qu, J., Erhard, K.F., Mack, J.F., Raha, K., Rendina, A.R., Szewczuk, L.M., Kratz, P.M., Jurewicz, A.J., Cecconie, T., Martens, S., McDevitt, P.J., Martin, J.D., Chen, S.B., Jiang, Y., Nickels, L., Schwartz, B.J., Smallwood, A., Zhao, B., Campobasso, N., Qian, Y., Briand, J., Rominger, C.M., Oleykowski, C., Hardwicke, M.A., Luengo, J.I. Acs Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2016-01-06
Resolution	2.730
CATH Insert Date	10 Apr, 2016

PDB Images (11)

Image of CATH 5hex

5hex

PDB 5hex

Image of CATH 5hexA

5hexA

PDB Chain 5hexA

Image of CATH 5hexB

5hexB

PDB Chain 5hexB

Image of CATH 5hexA01

5hexA01

CATH Domain 5hexA01

Image of CATH 5hexA02

5hexA02

CATH Domain 5hexA02

Image of CATH 5hexA03

5hexA03

CATH Domain 5hexA03

Image of CATH 5hexA04

5hexA04

CATH Domain 5hexA04

Image of CATH 5hexB01

5hexB01

CATH Domain 5hexB01

Image of CATH 5hexB02

5hexB02

CATH Domain 5hexB02

Image of CATH 5hexB03

5hexB03

CATH Domain 5hexB03

Image of CATH 5hexB04

5hexB04

CATH Domain 5hexB04

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	11 Apr, 2016	Chopped
B	11 Apr, 2016	Chopped

CATH Domains (8)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5hexA01	21 Feb, 2018	3.40.367.20	Assigned
5hexA02	21 Feb, 2018	3.30.420.40	Assigned
5hexA03	21 Feb, 2018	3.40.367.20	Assigned
5hexA04	21 Feb, 2018	3.30.420.40	Assigned
5hexB01	21 Feb, 2018	3.40.367.20	Assigned
5hexB02	21 Feb, 2018	3.30.420.40	Assigned
5hexB03	21 Feb, 2018	3.40.367.20	Assigned
5hexB04	21 Feb, 2018	3.30.420.40	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P52789	HXK2_HUMAN	Homo sapiens	Hexokinase-2
P52789	HXK2_HUMAN	Homo sapiens	Hexokinase-2