PDB 5hbj

PDB Information

PDB5HBJ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
Mallinger, A., Schiemann, K., Rink, C., Stieber, F., Calderini, M., Crumpler, S., Stubbs, M., Adeniji-Popoola, O., Poeschke, O., Busch, M., Czodrowski, P., Musil, D., Schwarz, D., Ortiz-Ruiz, M.J., Schneider, R., Thai, C., Valenti, M., de Haven Brandon, A., Burke, R., Workman, P., Dale, T., Wienke, D., Clarke, P.A., Esdar, C., Raynaud, F.I., Eccles, S.A., Rohdich, F., Blagg, J.
J.Med.Chem.
HeaderTransferase
Released2015-12-31
Resolution3.000
CATH Insert Date10 Apr, 2016

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5hbjA01 13 May, 2016 3.30.200.20 Assigned
5hbjA02 13 May, 2016 1.10.510.10 Assigned
5hbjB01 13 May, 2016 1.10.472.10 Assigned
5hbjB02 13 May, 2016 1.10.472.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P24863 CCNC_HUMAN Homo sapiens Cyclin-C
P49336 CDK8_HUMAN Homo sapiens Cyclin-dependent kinase 8