PDB 5gsa

PDB Information

PDB5GSA
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Qi, W., Zhao, K., Gu, J., Huang, Y., Wang, Y., Zhang, H., Zhang, M., Zhang, J., Yu, Z., Li, L., Teng, L., Chuai, S., Zhang, C., Zhao, M., Chan, H., Chen, Z., Fang, D., Fei, Q., Feng, L., Feng, L., Gao, Y., Ge, H., Ge, X., Li, G., Lingel, A., Lin, Y., Liu, Y., Luo, F., Shi, M., Wang, L., Wang, Z., Yu, Y., Zeng, J., Zeng, C., Zhang, L., Zhang, Q., Zhou, S., Oyang, C., Atadja, P., Li, E.
Nat. Chem. Biol.
HeaderTransferase/Transferase Inhibitor
Released2016-08-15
Resolution2.490
CATH Insert Date07 May, 2017

PDB Images (7)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Rejected
D 08 May, 2017 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5gsaA00 12 May, 2017 2.130.10.10 Assigned
5gsaB00 12 May, 2017 2.130.10.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O75530 EED_HUMAN Homo sapiens Polycomb protein EED
Q15910 EZH2_HUMAN Homo sapiens Histone-lysine N-methyltransferase EZH2
Q15910 EZH2_HUMAN Homo sapiens Histone-lysine N-methyltransferase EZH2
O75530 EED_HUMAN Homo sapiens Polycomb protein EED