PDB 5enm

PDB Information

PDB5ENM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain A beta Reduction in Rodents.
Wu, Y.J., Guernon, J., Yang, F., Snyder, L., Shi, J., Mcclure, A., Rajamani, R., Park, H., Ng, A., Lewis, H., Chang, C., Camac, D., Toyn, J.H., Ahlijanian, M.K., Albright, C.F., Macor, J.E., Thompson, L.A.
Acs Med.Chem.Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-11-09
Resolution1.980
CATH Insert Date16 Oct, 2016

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 17 Oct, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5enmA01 21 Oct, 2016 2.40.70.10 Assigned
5enmA02 21 Oct, 2016 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1