PDB 5ek9

PDB Information

PDB5EK9
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Shadrick, W.R., Slavish, P.J., Chai, S.C., Waddell, B., Connelly, M., Low, J.A., Tallant, C., Young, B.M., Bharatham, N., Knapp, S., Boyd, V.A., Morfouace, M., Roussel, M.F., Chen, T., Lee, R.E., Kiplin Guy, R., Shelat, A.A., Potter, P.M.
Bioorg. Med. Chem.
HeaderTranscription
Released2015-11-03
Resolution2.080
CATH Insert Date27 Nov, 2016

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 28 Nov, 2016 Chopped
B 28 Nov, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5ek9A00 01 Dec, 2016 1.20.920.10 Assigned
5ek9B00 01 Dec, 2016 1.20.920.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2
P25440 BRD2_HUMAN Homo sapiens Bromodomain-containing protein 2