PDB 5ebt

PDB Information

PDB5EBT
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Johannes, J.W., Almeida, L., Daly, K., Ferguson, A.D., Grosskurth, S.E., Guan, H., Howard, T., Ioannidis, S., Kazmirski, S., Lamb, M.L., Larsen, N.A., Lyne, P.D., Mikule, K., Ogoe, C., Peng, B., Petteruti, P., Read, J.A., Su, N., Sylvester, M., Throner, S., Wang, W., Wang, X., Wu, J., Ye, Q., Yu, Y., Zheng, X., Scott, D.A.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-10-19
Resolution2.240
CATH Insert Date10 Apr, 2016

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped
C 11 Apr, 2016 Chopped
D 11 Apr, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5ebtA00 08 May, 2016 3.90.228.10 Assigned
5ebtB00 08 May, 2016 3.90.228.10 Assigned
5ebtC00 08 May, 2016 3.90.228.10 Assigned
5ebtD00 08 May, 2016 3.90.228.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1
O95271 TNKS1_HUMAN Homo sapiens Poly [ADP-ribose] polymerase tankyrase-1