PDB 5cep

PDB Information

PDB5CEP
MethodX-RAY DIFFRACTION
Host OrganismTrichoplusia ni
Gene SourceHomo sapiens
Primary Citation
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).
Patel, S., Harris, S.F., Gibbons, P., Deshmukh, G., Gustafson, A., Kellar, T., Lin, H., Liu, X., Liu, Y., Liu, Y., Ma, C., Scearce-Levie, K., Ghosh, A.S., Shin, Y.G., Solanoy, H., Wang, J., Wang, B., Yin, J., Siu, M., Lewcock, J.W.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2015-07-07
Resolution1.990
CATH Insert Date25 Oct, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 26 Oct, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5cepA01 23 Dec, 2016 3.30.200.20 Assigned
5cepA02 23 Dec, 2016 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q12852 M3K12_HUMAN Homo sapiens Mitogen-activated protein kinase kinase kinase 12