PDB 4zyf

PDB Information

PDB4ZYF
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.
Holzer, P., Masuya, K., Furet, P., Kallen, J., Valat-Stachyra, T., Ferretti, S., Berghausen, J., Bouisset-Leonard, M., Buschmann, N., Pissot-Soldermann, C., Rynn, C., Ruetz, S., Stutz, S., Chene, P., Jeay, S., Gessier, F.
J.Med.Chem.
HeaderCell Cycle
Released2015-05-21
Resolution1.800
CATH Insert Date16 Aug, 2015

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 17 Aug, 2015 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
4zyfA00 20 Mar, 2016 1.10.245.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q00987 MDM2_HUMAN Homo sapiens E3 ubiquitin-protein ligase Mdm2
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