PDB 4zx8

PDB Information

PDB4ZX8
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourcePlasmodium falciparum FcB1/Columbia
Primary Citation
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Drinkwater, N., Vinh, N.B., Mistry, S.N., Bamert, R.S., Ruggeri, C., Holleran, J.P., Loganathan, S., Paiardini, A., Charman, S.A., Powell, A.K., Avery, V.M., McGowan, S., Scammells, P.J.
Eur.J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-05-20
Resolution2.700
CATH Insert Date10 Apr, 2016

PDB Images (37)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 11 Apr, 2016 Chopped
B 11 Apr, 2016 Chopped
C 11 Apr, 2016 Chopped
D 11 Apr, 2016 Chopped
E 11 Apr, 2016 Chopped
F 11 Apr, 2016 Chopped
G 11 Apr, 2016 Chopped
H 11 Apr, 2016 Chopped
I 11 Apr, 2016 Chopped
J 11 Apr, 2016 Chopped
K 11 Apr, 2016 Chopped
L 11 Apr, 2016 Chopped

CATH Domains (24)

Domain ID Date inserted into CATH Superfamily CATH Status
4zx8A01 03 May, 2016 3.40.220.10 Assigned
4zx8A02 03 May, 2016 3.40.630.10 Assigned
4zx8B01 03 May, 2016 3.40.220.10 Assigned
4zx8B02 03 May, 2016 3.40.630.10 Assigned
4zx8C01 03 May, 2016 3.40.220.10 Assigned
4zx8C02 03 May, 2016 3.40.630.10 Assigned
4zx8D01 03 May, 2016 3.40.220.10 Assigned
4zx8D02 03 May, 2016 3.40.630.10 Assigned
4zx8E01 03 May, 2016 3.40.220.10 Assigned
4zx8E02 03 May, 2016 3.40.630.10 Assigned
4zx8F01 03 May, 2016 3.40.220.10 Assigned
4zx8F02 03 May, 2016 3.40.630.10 Assigned
4zx8G01 03 May, 2016 3.40.220.10 Assigned
4zx8G02 03 May, 2016 3.40.630.10 Assigned
4zx8H01 03 May, 2016 3.40.220.10 Assigned
4zx8H02 03 May, 2016 3.40.630.10 Assigned
4zx8I01 03 May, 2016 3.40.220.10 Assigned
4zx8I02 03 May, 2016 3.40.630.10 Assigned
4zx8J01 03 May, 2016 3.40.220.10 Assigned
4zx8J02 03 May, 2016 3.40.630.10 Assigned
4zx8K01 03 May, 2016 3.40.220.10 Assigned
4zx8K02 03 May, 2016 3.40.630.10 Assigned
4zx8L01 03 May, 2016 3.40.220.10 Assigned
4zx8L02 03 May, 2016 3.40.630.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein
A0A024V0B1 A0A024V0B1_PLAFA Plasmodium falciparum Vietnam Oak-Knoll (FVO) Uncharacterized protein