PDB 4ztn

PDB Information

PDB4ZTN
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHomo sapiens
Primary Citation
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
Seganish, W.M., Fischmann, T.O., Sherborne, B., Matasi, J., Lavey, B., McElroy, W.T., Tulshian, D., Tata, J., Sondey, C., Garlisi, C.G., Devito, K., Fossetta, J., Lundell, D., Niu, X.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-05-14
Resolution2.230
CATH Insert Date20 Sep, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped
C 21 Sep, 2015 Chopped
D 21 Sep, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4ztnA01 30 Sep, 2015 3.30.200.20 Assigned
4ztnA02 30 Sep, 2015 1.10.510.10 Assigned
4ztnB01 30 Sep, 2015 3.30.200.20 Assigned
4ztnB02 30 Sep, 2015 1.10.510.10 Assigned
4ztnC01 30 Sep, 2015 3.30.200.20 Assigned
4ztnC02 30 Sep, 2015 1.10.510.10 Assigned
4ztnD01 30 Sep, 2015 3.30.200.20 Assigned
4ztnD02 30 Sep, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4