PDB 4zk5

PDB Information

PDB4ZK5
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.
Ndubaku, C.O., Crawford, T.D., Chen, H., Boggs, J.W., Drobnick, J., Harris, S.F., Jesudason, R., McNamara, E., Nonomiya, J., Sambrone, A., Schmidt, S., Smyczek, T., Vitorino, P., Wang, L., Wu, P., Yeung, S., Chen, J., Chen, K., Ding, C.Z., Wang, T., Xu, Z., Gould, S.E., Murray, L.J., Ye, W.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-04-29
Resolution2.890
CATH Insert Date20 Sep, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4zk5A01 30 Sep, 2015 3.30.200.20 Assigned
4zk5A02 30 Sep, 2015 1.10.510.10 Assigned
4zk5B01 30 Sep, 2015 3.30.200.20 Assigned
4zk5B02 30 Sep, 2015 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O95819 M4K4_HUMAN Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4
O95819 M4K4_HUMAN Homo sapiens Mitogen-activated protein kinase kinase kinase kinase 4