PDB 4zjj

PDB Information

PDB4ZJJ
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.
Karpov, A.S., Amiri, P., Bellamacina, C., Bellance, M.H., Breitenstein, W., Daniel, D., Denay, R., Fabbro, D., Fernandez, C., Galuba, I., Guerro-Lagasse, S., Gutmann, S., Hinh, L., Jahnke, W., Klopp, J., Lai, A., Lindvall, M.K., Ma, S., Mobitz, H., Pecchi, S., Rummel, G., Shoemaker, K., Trappe, J., Voliva, C., Cowan-Jacob, S.W., Marzinzik, A.L.
Acs Med.Chem.Lett.
HeaderTransferase
Released2015-04-29
Resolution2.200
CATH Insert Date28 Jun, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4zjjA01 27 Jul, 2015 3.30.200.20 Assigned
4zjjA02 27 Jul, 2015 1.10.510.10 Assigned
4zjjB01 27 Jul, 2015 3.30.200.20 Assigned
4zjjB02 27 Jul, 2015 1.10.510.10 Assigned
4zjjC01 27 Jul, 2015 3.30.200.20 Assigned
4zjjC02 27 Jul, 2015 1.10.510.10 Assigned
4zjjD01 27 Jul, 2015 3.30.200.20 Assigned
4zjjD02 27 Jul, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1