PDB Information

PDB4YBM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.
Palmer, W.S., Poncet-Montange, G., Liu, G., Petrocchi, A., Reyna, N., Subramanian, G., Theroff, J., Yau, A., Kost-Alimova, M., Bardenhagen, J.P., Leo, E., Shepard, H.E., Tieu, T.N., Shi, X., Zhan, Y., Zhao, S., Barton, M.C., Draetta, G., Toniatti, C., Jones, P., Geck Do, M., Andersen, J.N.
J.Med.Chem.
HeaderTranscription/Transcription Inhibitor
Released2015-02-18
Resolution1.460
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4ybmA01 22 Jul, 2015 3.30.40.10 Assigned
4ybmA02 22 Jul, 2015 1.20.920.10 Assigned
4ybmB01 22 Jul, 2015 3.30.40.10 Assigned
4ybmB02 22 Jul, 2015 1.20.920.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O15164 TIF1A_HUMAN Homo sapiens Transcription intermediary factor 1-alpha
O15164 TIF1A_HUMAN Homo sapiens Transcription intermediary factor 1-alpha