PDB 4xxs

PDB Information

PDB4XXS
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors.
Brodney, M.A., Beck, E.M., Butler, C.R., Barreiro, G., Johnson, E.F., Riddell, D., Parris, K., Nolan, C.E., Fan, Y., Atchison, K., Gonzales, C., Robshaw, A.E., Doran, S.D., Bundesmann, M.W., Buzon, L., Dutra, J., Henegar, K., LaChapelle, E., Hou, X., Rogers, B.N., Pandit, J., Lira, R., Martinez-Alsina, L., Mikochik, P., Murray, J.C., Ogilvie, K., Price, L., Sakya, S.M., Yu, A., Zhang, Y., O'Neill, B.T.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-01-30
Resolution1.860
CATH Insert Date28 Jun, 2015

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
4xxsA01 22 Jul, 2015 2.40.70.10 Assigned
4xxsA02 22 Jul, 2015 2.40.70.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P56817 BACE1_HUMAN Homo sapiens Beta-secretase 1