PDB Information

PDB4XX4
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceHomo sapiens
Primary Citation
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
McKittrick, B.A., Caldwell, J.P., Bara, T., Boykow, G., Chintala, M., Clader, J., Czarniecki, M., Courneya, B., Duffy, R., Fleming, L., Giessert, R., Greenlee, W.J., Heap, C., Hong, L., Huang, Y., Iserloh, U., Josien, H., Khan, T., Korfmacher, W., Liang, X., Mazzola, R., Mitra, S., Moore, K., Orth, P., Rajagopalan, M., Roy, S., Sakwa, S., Strickland, C., Vaccaro, H., Voigt, J., Wang, H., Wong, J., Zhang, R., Zych, A.
Bioorg. Med. Chem. Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-01-29
Resolution2.400
CATH Insert Date28 Jun, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4xx4A01 22 Jul, 2015 2.40.70.10 Assigned
4xx4A02 22 Jul, 2015 2.40.70.10 Assigned
4xx4B01 20 Jul, 2015 2.40.70.10 Assigned
4xx4B02 20 Jul, 2015 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00797 RENI_HUMAN Homo sapiens Renin
P00797 RENI_HUMAN Homo sapiens Renin
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