PDB Information

PDB4XU2
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceMycobacterium tuberculosis
Primary Citation
Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
Bockman, M.R., Kalinda, A.S., Petrelli, R., De la Mora-Rey, T., Tiwari, D., Liu, F., Dawadi, S., Nandakumar, M., Rhee, K.Y., Schnappinger, D., Finzel, B.C., Aldrich, C.C.
J.Med.Chem.
HeaderLigase/Ligase Inhibitor
Released2015-01-24
Resolution1.850
CATH Insert Date20 Sep, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4xu2A01 30 Sep, 2015 3.30.930.10 Assigned
4xu2A02 30 Sep, 2015 2.30.30.100 Assigned
4xu2B01 30 Sep, 2015 3.30.930.10 Assigned
4xu2B02 30 Sep, 2015 2.30.30.100 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
I6YFP0 I6YFP0_MYCTU Mycobacterium tuberculosis H37Rv Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase)
I6YFP0 I6YFP0_MYCTU Mycobacterium tuberculosis H37Rv Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase)